What does the term "erythema multiforme" refer to?

Erythema multiforme is a condition that is primarily characterized by a hypersensitivity reaction involving the skin and mucous membranes. It presents as target lesions which are often described as having a characteristic “target” or “bull's-eye” appearance with a varying degree of central necrosis, surrounded by an erythematous halo. This condition is commonly triggered by infections, particularly viral infections like herpes simplex, medications, or sometimes idiopathic causes.

The correct understanding of erythema multiforme highlights its immunological basis and recognition of the distinct morphology of the lesions, which can help differentiate it from other dermatological conditions. This distinction is critical for appropriate diagnosis and management, as it can indicate underlying systemic issues or the need for further evaluation, particularly if recurrent or extensive.