Which condition is characterized by the presence of multiple seborrheic keratoses?

The presence of multiple seborrheic keratoses is indeed characteristically associated with Leser-Trélat sign. This sign refers to the sudden eruption of numerous seborrheic keratoses, often accompanied by underlying malignancy, typically gastric adenocarcinoma. While seborrheic keratoses are common benign skin lesions that can occur sporadically, their sudden appearance in abundance can indicate a paraneoplastic syndrome.

Understanding this connection is crucial, as it serves as a clinical marker prompting further investigation for potential malignancies, particularly in older patients. In contrast, the other conditions listed do not typically present with multiple seborrheic keratoses.

Keratoacanthoma is a distinct, dome-shaped lesion that may resemble squamous cell carcinoma but does not feature the multiple lesions characteristic of seborrheic keratoses. Basal cell carcinoma is a common type of skin cancer that usually presents as a solitary lesion, although it can occur in multiple forms, it is not typically identified by the emergence of seborrheic keratoses. Psoriasis is a chronic inflammatory skin condition that presents as erythematous plaques with silvery scales, which is not related to seborrheic keratoses.