Which medication is often used for severe systemic acne?

Oral isotretinoin is widely recognized as a highly effective treatment for severe systemic acne, also known as nodular acne or cystic acne, which does not respond well to standard topical treatments or antibiotic therapies. This medication is a retinoid derived from vitamin A and works by decreasing sebum production, inhibiting the growth of acne-causing bacteria, and promoting the turnover of skin cells. Due to its potent effects, isotretinoin can lead to significant improvement in acne and is often used in cases where other treatments have failed.

Although other options, such as topical benzoyl peroxide, minocycline, and clindamycin, are beneficial for treating acne, they are more suitable for milder or moderate cases. Topical benzoyl peroxide targets surface bacteria and helps to unclog pores, but it may not be sufficient for severe cases. Minocycline, an oral antibiotic, can reduce bacteria and inflammation but may not adequately address the severe form of acne that requires a more aggressive approach. Clindamycin, another topical antibiotic, can also be effective for localized acne but lacks the systemic effect necessary for widespread, severe cases.

In summary, oral isotretinoin stands out as the preferred option for severe