Which skin condition often presents with a "bull's-eye" appearance?

The skin condition that often presents with a "bull's-eye" appearance is Lyme disease. This characteristic rash is known as erythema migrans, which typically appears at the site of a tick bite. The rash usually starts as a small red spot that expands over time, creating the classic concentric rings that resemble a target or bull's-eye.

In the context of Lyme disease, this rash forms as the body’s immune response to the infection from the Borrelia burgdorferi bacteria, which are transmitted through tick bites. The center of the rash may clear as it expands outward, leading to this distinctive appearance.

Understanding the presentation of erythema migrans is crucial for early diagnosis and treatment of Lyme disease, as prompt management is essential to prevent further complications associated with the illness. This unique presentation distinguishes Lyme disease from other conditions listed, which do not typically exhibit a bull's-eye pattern on the skin.