Which skin condition often presents with intense itching and blisters?

Eczema, particularly atopic dermatitis, is characterized by intense itching and the formation of blisters, especially during flare-ups. This condition results from a combination of genetic and environmental factors affecting the skin's barrier function, leading to dry, inflamed, and itchy skin. The itch-scratch cycle in eczema can cause the skin to break down and develop blisters, which may weep and crust over.

The presentation of intense itching is a hallmark symptom, as patients often describe severe discomfort and a compulsion to scratch the affected areas, which can exacerbate the condition. Blistering can occur during acute flare-ups, particularly when the skin becomes highly inflamed. This feature distinguishes eczema from other skin conditions listed.

In contrast, psoriasis typically manifests as silvery, scaly plaques that may be itchy but are not characterized predominantly by blister formation. Rosacea is primarily associated with facial flushing, redness, and sometimes papules or pustules, but it does not usually present with blisters or intense itching. Actinic keratosis appears as dry, rough patches on sun-exposed areas and is not known for causing itching or blisters. Therefore, eczema is the skin condition that fits the description of intense itching and blister formation most closely.